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Publications

Main Publications

 
 
M. Brand*, K. Nakka, J. Zhu & F.J. Dilworth*.  Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function. *co-corresponding  Cell Stem Cell, 24(4): 518-533, 2019

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C.G. Palii*, Q. Cheng*, M.A. Gillespie, P. Shannon, M. Mazurczyk, G. Napolitani, N.D. Price, J.A. Ranish, E. Morrissey**, D.R. Higgs** & M. Brand**.  Single cell proteomics reveal that quantitative changes in co-expressed lineage-specific transcription factors determine cell-fate. *co-first **co-senior  Cell Stem Cell (2019), https://doi.org/10.1016/j.stem.2019.02.006 (Featured Article)

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C.G. Palii*, Q. Cheng*, M.A. Gillespie, M. Mazurczyk, G. Napolitani, J.A. Ranish, E. Morrissey**, D.R. Higgs** & M. Brand** .  Single cell proteomics reveal that temporal changes in transcription factors determine cell-fate.  *co-first   **co-senior  (Pre-print posted on Nov 2, 2018)
 
 
 
S. Fraineau, C.G Palii, B. McNeill, M. Ritso, W.C. Shelley, N. Prasain, A. Chu, E. Vion, K. Rieck, S. Nilufar, T.J. Perkins, M.A. Rudnicki, D.S. Allan, M.C. Yoder, E.J. Suuronen & M. Brand.   Epigenetic Activation of Pro-angiogenic Signaling Pathways in Human Endothelial Progenitors Increases Vasculogenesis.   Stem Cell Reports, 9(5): 1573-1587, 2017

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A. Benyoucef, C.G. Palii, C. Wang, C.J. Porter, A. Chu, F. Dai, V. Tremblay, P. Rakopoulos, K. Singh, S. Huang, F. Pflumio, J. Hebert, J-F. Couture, T.J. Perkins, K. Ge, F.J. Dilworth & M. Brand.  UTX inhibition as a selective epigenetic therapy against TAL1-driven T-cell Acute Lymphoblastic Leukemia .   Genes & Development, 30(5): 508-521, 2016 (Page Cover)

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M. Brand.   Pharmacologic Control of Chromatin Looping.   Blood, 126(5): 569-570, 2015

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G.A Blobel, D. Bodine, M. Brand,  J. Crispino, M.F.T.R de Bruijn, D. Nathan, T. Pappayannopoulou, C. Porcher, J. Strouboulis, L. Zon, D.R. Higgs, G. Stamatoyannopoulos & J.D. Engel.  An International Effort to Cure a Global Health Problem: A report on the 19th Hemoglobin Switching ConferenceExperimental Hematology, 43(10): 821-837, 2015

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A. Benyoucef & M. Brand.  Epigenetic Gene Regulation and Stem Cell Function.  Translational Epigenetics Series, Epigenetic Gene Expression and Regulation, 7: 149-181, 2015

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S. Fraineau, C.G. Palii, D.S. Allan & M. Brand.  Epigenetic Regulation of Endothelial Cell-mediated Vascular Repair.   FEBS Journal, 282(9): 1605-1629, 2015 (Page Cover)

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C.G. Palii, B. Vulesevic, S. Fraineau, E. Pranckeviciene, A.J. Griffith, A. Chu, H. Faralli, Y. Li, B. McNeill, J. Sun, T.J. Perkins, F.J. Dilworth, C. Perez-Iratxeta, E.J. Suuronen, D.S. Allan & M. Brand Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes.    Cell Stem Cell, 14(5): 644-657, 2014 (Featured article)

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C-P. Chaturvedi & M. Brand.  EHMT2 (euchromatic histone-lysine N-methyltransferase 2)  Atlas of Genetics and Cytogenetics in Oncology and Haematology 18(1): 38-45, 2014

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C-P. Chaturvedi, B. Somasundaram, K.Singh, R.L. Carpenedo, W.L. Stanford, F.J. Dilworth & M. Brand. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proceedings of the National Academy of Sciences USA, 109(46): 18845-18850, 2012

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L. Guevel, J.R. Lavoie, C. Perez-Iratxeta, K. Rouger, L. Dubreil, M. Feron, S. Talon M. Brand* & L. Megeney*. Quantitative proteomic analysis of dystrophic dog muscle. Journal of Proteome Research 10 (5): 2465-2478, 2011
*share equal contribution as senior authors

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C.G. Palii*, C. Perez-Iratxeta*, Z. Yao, Y. Cao, F. Dai, J. Davison, H. Atkins, D. Allan, F.J. Dilworth, R. Gentleman, S.J. Tapscott & M. Brand. Differential genomic targeting of the transcription factor TAL1 in alternate hematopoietic lineages. The EMBO Journal  30 (3): 494-509, 2011 (Epub Dec 21, 2010)
*equal contribution

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Supplementary Tables

 
 
C.G. Palii, R. Pasha & M. Brand. Lentiviral-mediated knockdown during ex vivo erythropoiesis of human hematopoietic stem cells. Journal of Visualized Experiments  doi: 10.3791/2813. J Vis Exp. 53, 2011

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A.M. Hosey, C-P Chaturvedi & M. Brand. Crosstalk between histone modifications maintains the developmental pattern of gene expression on a tissue-specific locus.
Epigenetics 5 (4):273-281, 2010

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C-P. Chaturvedi*, A.M. Hosey*, C. Palii, C. Perez-Iratxeta, Y. Nakatani, J.A. Ranish, F.J. Dilworth & M. Brand. Dual role for the methyltransferase G9a in the maintenance of ß-globin gene transcription in adult erythroid cells. Proceedings of the National Academy of Sciences USA, 106 (43): 18303-18308, 2009
*equal contribution

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A.M. Hosey & M. Brand. Chromatin-mediated spreading on active genes. Nature Structural and Molecular Biology 16 (1): 11-13, 2009

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M. Brand, S. Rampalli, C-P. Chaturvedi, and F.J. Dilworth. Analysis of epigenetic modifications of chromatin at specific gene loci by native chromatin immunoprecipitation (N-ChIP) of nucleosomes isolated using hydroxyapatite chromatography. Nature Protocols 3 (3): 398-409, 2008

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C. Demers, C.P. Chaturvedi, J. A. Ranish, G. Juban, P. Lai, F. Morle, R. Aebersold, F. Dilworth, M. Groudine and M. Brand. Activator-mediated Recruitment of the MLL2 Methyltransferase Complex to the ß-globin Locus.  Molecular Cell, 27: 573-584, 2007

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J.A Ranish, M. Brand and R. Aebersold. Using stable isotope tagging and MS to characterize protein complexes and to detect changes in their composition. Methods Mol Biol. 359:17-35, 2007

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M. Brand, J. A. Ranish, N. T. Kummer, J. Hamilton, K. Igarashi, C. Francastel, T. Chi, G. R. Crabtree, R. Aebersold and M. Groudine. Dynamic changes in transcription factors complexes during erythroid differentiation revealed by quantitative proteomics. Nature Structural and Molecular Biology, 11 (1): 73-80, 2004

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S. Hardy*, M. Brand*, G. Mittler, J. Yanagisawa, S. Kato, M. Meisterernst and L. Tora. TATA-binding protein-Free TAF-containing complex (TFTC) and p300 are both required for efficient transcriptional activation. Journal of Biological Chemistry 277: 32875-32882, 2002
*equal contribution

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M. Brand, J. G. Moggs, M. Oulad-Abdelghani, F. Lejeune, F. J. Dilworth, J. Stevenin, G. Almouzni and L. Tora. UV-damaged DNA binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. The EMBO Journal 20 (12): 3187-3196, 2001

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M. Brand*, C. Leurent*, V. Mallouh, L. Tora and P. Schultz. Three dimensional structures of the TAFII-containing complexes TFIID and TFTC. Science 286: 2151-2153, 1999
*equal contribution

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M. Brand, K. Yamamoto, A. Staub and L.Tora. Identification of TFTC subunits suggests a role in nucleosome acetylation and signal transduction. Journal of Biological Chemistry 274 (26): 18285-18289, 1999

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E. Wieczorek*, M. Brand*, X. Jacq and L. Tora. Function of TAFII-containing complex without TBP in transcription by RNA polymerase II. Nature  393: 187-191, 1998
*equal contribution

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Other Publications

 
R. Rao, A. Ketkar, N. Kedia, V. Krishnamoorthy, V. Lakshmanan, P. Kumar, A. Mohanty, S.O. Raja, S.D. Kumar, A. Gulyani, C-P. Chaturvedi, M. Brand, D. Palakodeti & S. Rampalli.  KMT1 family methyltransferases regulate heterochromatin-nuclear periphery tethering via histone and non-histone protein methylation.  EMBO Reports, e4326, 2019

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Ketkar, R.A. Rao, N. Kedia, F. Ravindran, V. Lakshmanan, P. Kumar, A. Mohanty, S.D. Kumar, S.O. Raja, A. Gulyani, C-P. Chaturvedi, M. Brand, D. Palakodeti & S. Rampalli.  Euchromatic histone methyltransferases regulate peripheral heterochromatin tethering via histone and non-histone protein methylations.  (Pre-print posted on BioRxiv on Jan 2, 2018)
 
 
 
S.Han, D.J. Dennis, A. Balakrishnan, R. Dixit, O. Britz, D. Zinyk, Y. Touahri, T. Olender, M. Brand, F. Guillemot, D. Kurrasch & C. Schuurmans. A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis.  Development, 145(19):

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J.F. Haddad*, Y. Yang*, Y. Takahashi, M. Joshi, N. Chaudhary, A.R. Woodfin, A. Benyoucef, S. Yeung, J.S. Brunzelle, G. Skiniotis, M. Brand, A. Shilatifard & J-F. Couture. Structural analysis of the Ash2L/Dpy-30 complex reveals a heterogeneity in H3K4 methylation.  *co-first  Structure, 26:1-10 https://doi.org/10.1016/j.str.2018.08.004, 2018

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J. Barrera-Ramirez, J.R. Lavoie, H.B. Maganti, W.L. Stanford, C. Ito, M. Sabloff, M. Brand, M. Rosu-Myles, Y. Le & D. Allan. Micro RNA profiling of exosomes from marrow-derived mesenchymal stromal cells in patients with acute myeloid leukemia: implications in leukemogenesis. Stem Cell Reviews and Reports, 13(6): 817-825, https://doi.org/10.1007/s12015-017-9762-0, 2017

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H. Faralli, C. Wang, A.K. Nakka, A. Benyoucef, S. Sebastian, L. Zhuang, A. Chu, C., C.G. Palii, C. Liu, B. Camellato, M. Brand, K. Ge & F.J. Dilworth.  H3K27-demethylase activity of UTX/KDM6A is essential for skeletal muscle regeneration.   Journal of Clinical Investigation, 126(4): 1555-1565, 2016

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Y. Le, S. Fraineau, P. Chandran, M. Sabloff, M. Brand, J.R. Lavoie, R. Gagne, M. Rosu-Myles, C.L. Yauk, R.B. Richardson & D.S. Allan. Adipogenic Mesenchymal Stromal Cells from Bone Marrow and their Hematopoietic Supportive Role: Towards an Understanding of a Permissive Marrow Microenvironment in Acute Myeloid Leukemia. Stem Cell Reviews and Reports. Epub ahead of print. Dec 9, 2015

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P. Zhang, C.P. Chaturvedi, V. Tremblay, M. Cramet, J.S. Brunzelle, G. Skiniotis, M. Brand, A. Shilatifard & J.F. Couture.  A phosphorylation Switch on RbBP5 regulates Histone H3 Lys4 Methylation.   Genes and Development, 29: 123-128, 2015

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V. Tremblay, P. Zhang, C.P. Chaturvedi, J. Thornton, J.S. Brunzelle, G. Skiniotis, A. Shilatifard, M. Brand & J.F. Couture.  Molecular Basis for DPY-30 Association to COMPASS-like and NURF Complexes.   Structure, 22(12): 1821-1830, 2014

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M. Andrade-Navarro, F. Kanji, C.G. Palii, M. Brand, H. Atkins & C. Perez-Iratxeta. A method for cell type marker discovery by high-throughput gene expression analysis of mixed cell populations.    BMC Biotechnology, 13: 80, 2013

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 M.R. Mansour, T. Sanda, L.N. Lawton, X. Li, T. Kreslavsky, C.D. Novina, M. Brand, A. Gutierrez, M.A. Kelliher, C.H. Jamieson, H. von Boehmer, R.A. Young & A.T. Look.  The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia Journal of Experimental Medicine 210(8): 1545-1557, 2013

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S. Sebastian, H. Faralli, Z. Yao, P. Rakopoulos, C. Palii, Y. Cao, K. Singh, Q-C. Liu, A. Chu, A. Aziz, M. Brand, S.J. Tapscott & F.J. Dilworth.  Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation Genes & Development 27: 1247-1259, 2013

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S. Li, P. Mattar, D. Zinyk, K. Singh, C-P. Chaturvedi, C. Kovach, R. Dixit, D.M. Kurrasch, Y. Ma, J.A. Chan, V. Wallace, F.J. Dilworth, M. Brand & C. Schuurmans .  GSK3 temporally regulates Neurogenin 2 proneural activity in the neocortex. Journal of Neuroscience 32 (23): 7791-7805, 2012

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  L. Labonté, Y. Li, C.L. Addison, M. Brand, H. Javidnia, M. Corsten, K. Burns & D.S. Allan .  Distinct profile of vascular progenitor attachment to extracellular matrix proteins in cancer patients. Clinical and Investigative Medicine 35 (2): E86-95, 2012

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Y. Li, C. Deng, X. Hu, X. Fu, Y. Qiu, M. Brand, K. Zhao & S. Huang.  Dynamic interaction between TAL1 and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis. Oncogene, Epub ahead of print February 6, 2012

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S. Sarvan*, V. Avdic*, V. Tremblay*, C-P. Chaturvedi, P. Zhang, S. Lanouette, A. Blais, J.S. Brunzelle, M. Brand & J-F. Couture. Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain. Nature Structural and Molecular Biology18 (7): 857-859, 2011
* equal contribution

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S. Rampalli, L. Li, E. Mak, K. Ge, M. Brand, S.J. Tapscott, and F.J. Dilworth. p38 MAPK signaling pathway regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Nature Structural and Molecular Biology 14: 1150-1156, 2007

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A. Kim, S. Song, M. Brand and A. Dean. Nucleosome and transcription activator antagonism at human ß-globin locus control region DNase I hypersensitive sites. Nucleic Acids Research 35 (17): 5831-5838, 2007

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J. Sun, M. Brand, Y. Zenke, S. Tashiro, M. Groudine and K. Igarashi. Heme regulates dynamics of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proceedings of the National Academy of Sciences, 101 (6): 1461-1466, 2004

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N. Cavusoglu,  M. Brand, L. Tora and A. Van Dorsselaer. Novel subunits of the TATA Binding Protein Free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one dimensional gel electrophoresis. Proteomics, 3 (2): 217-223, 2003

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Y. G. Gangloff, J. C. Pointud, S. Thuault, L. Carre, C. Romier, S. Muratoglu, M. Brand, L. Tora, J. L. Couderc and I. Davidson. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. Molecular and Cellular Biology 21 (15): 5109-51021, 2001

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L. Tora, M. Brand, E. Wieczorek and D. Metzger. The role of TAFII30-containing complexes in vertebrate gene regulation. in: Human Frontier Workshop VII on "Transcription Regulation in Eukaryotes" Eds. P. Chambon, R.D. Kornberg, T. Fukasawa and C. Coath. HFSP, Strasbourg, France. pp. 162-170, 1999

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